Background: the improved survival of TM patients has allowed new complications to develop in the age adult. Pulmonary dysfunction is one of complications of TM. Aim of the study: to evaluate spirometric pattern, lung diffusion and exercise capacity in TM adult patients. Methods: 24 TM adult patients [14 m,10 f range age 19-45] were included. All patients received periodical transfusion and were under chelation therapy. Three patients were active smokers (10±2 pack/years). All patients underwent: dosage of serum ferritin levels, heart echography, complete spirometry, and six minute walking test (6MWT). Results: mean serum ferritin level was 882±112 ng/mL; Hb concentration 9,4±0.4 g/dL. All patients had normal cardiac ejection fraction (FE) (mean value 67.43±1,1 %). In three patients heart echography documented dilatative cardiomiopaty. Spirometry documented in 9 patients a restrictive ventilatory pattern. In 20 patients KCO was ≤60%. During 6MWT patients went through 539±46 metres. Mean SpO2 was 97,45±1.2 %, mean heart rate (HR) at rest and during 6MWT were 92±12 and 121.7±11 bpm respectively. A negative correlation was found between ferritin level and both FE (p<0.01; r =-0.53), and TLC (p<0.05; r =-0,47). A negative correlation was also found between HR during 6MWT and FE (p<0.05; r =-0,49). A positive correlation was found between KCO and distance during the 6MWT (p<0.05; r =0.51). Conclusion: this study indicates that increased iron load in TM patients leads to pulmonary complication.The high HR at rest and at peak exercise might be due to inactivity. An exercise training programm could be useful in these patients.
Pulmonary fuction and exercise capacity evaluation in adult thalassemic patients
GENNARI, Alessandra;FERRARO, Andrea;BORGNA, Caterina;COGO, Annaluisa
2006
Abstract
Background: the improved survival of TM patients has allowed new complications to develop in the age adult. Pulmonary dysfunction is one of complications of TM. Aim of the study: to evaluate spirometric pattern, lung diffusion and exercise capacity in TM adult patients. Methods: 24 TM adult patients [14 m,10 f range age 19-45] were included. All patients received periodical transfusion and were under chelation therapy. Three patients were active smokers (10±2 pack/years). All patients underwent: dosage of serum ferritin levels, heart echography, complete spirometry, and six minute walking test (6MWT). Results: mean serum ferritin level was 882±112 ng/mL; Hb concentration 9,4±0.4 g/dL. All patients had normal cardiac ejection fraction (FE) (mean value 67.43±1,1 %). In three patients heart echography documented dilatative cardiomiopaty. Spirometry documented in 9 patients a restrictive ventilatory pattern. In 20 patients KCO was ≤60%. During 6MWT patients went through 539±46 metres. Mean SpO2 was 97,45±1.2 %, mean heart rate (HR) at rest and during 6MWT were 92±12 and 121.7±11 bpm respectively. A negative correlation was found between ferritin level and both FE (p<0.01; r =-0.53), and TLC (p<0.05; r =-0,47). A negative correlation was also found between HR during 6MWT and FE (p<0.05; r =-0,49). A positive correlation was found between KCO and distance during the 6MWT (p<0.05; r =0.51). Conclusion: this study indicates that increased iron load in TM patients leads to pulmonary complication.The high HR at rest and at peak exercise might be due to inactivity. An exercise training programm could be useful in these patients.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
