This study examined whether mucus plugging and chronic bronchitis represent distinct mucus-related phenotypes in young adult smokers. In the BEACON cohort, mucus plugs were uncommon but were associated with greater FEV1 bronchodilator reversibility and a higher frequency of bronchodilator responsiveness, whereas chronic bronchitis—regardless of definition—showed no such association. Blood eosinophil counts did not differ between groups. These findings suggest that mucus plugging and chronic bronchitis reflect different underlying pathological processes in early smoking-related airway disease.
Linking mucus plugs and chronic bronchitis to bronchodilator responsiveness in young adult smokers: BEACON cohort
Baraldi, Federico;
2025
Abstract
This study examined whether mucus plugging and chronic bronchitis represent distinct mucus-related phenotypes in young adult smokers. In the BEACON cohort, mucus plugs were uncommon but were associated with greater FEV1 bronchodilator reversibility and a higher frequency of bronchodilator responsiveness, whereas chronic bronchitis—regardless of definition—showed no such association. Blood eosinophil counts did not differ between groups. These findings suggest that mucus plugging and chronic bronchitis reflect different underlying pathological processes in early smoking-related airway disease.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
