It is know that subset of T regulatory (T-reg) lymphocyte plays a role in modulating immune answer. T-reg can be immunophenotipically characterized by co-expression of CD4/CD25high and intracytoplasmatic FOXP3. In medical practice bone marrow transplantation is routinely employed in the treatment of immune diseases refractory to conventional therapy. The therapeutic effect of stem cell transplantation is due to differentiation of T lymphocytes in T-reg cells. After in vitro expansion, infusion of adequate amount of T reg cells might be considered a therapeutic choice in patients with autoimmune disease treated by bone marrow transplantation.
Role of T regulatory cells in transplantation of autoimmune diseases
Lanza F.;
2010
Abstract
It is know that subset of T regulatory (T-reg) lymphocyte plays a role in modulating immune answer. T-reg can be immunophenotipically characterized by co-expression of CD4/CD25high and intracytoplasmatic FOXP3. In medical practice bone marrow transplantation is routinely employed in the treatment of immune diseases refractory to conventional therapy. The therapeutic effect of stem cell transplantation is due to differentiation of T lymphocytes in T-reg cells. After in vitro expansion, infusion of adequate amount of T reg cells might be considered a therapeutic choice in patients with autoimmune disease treated by bone marrow transplantation.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
