An integrated chip-approach to study enentioselective heterogeneous catalyst at the microscale

In this work, we present novel approaches to study stereoselective catalytic processes at an unrivalled small scale. This is achieved by seamless on-chip integration of micro-sized chemical reactors and high performance liquid chromatography (HPLC)-columns on a single device. In contrast to our previous work, we present advanced chip-layouts and adapted strategies to transfer effluent samples from the reactor to the integrated HPLC column while keeping the flow through the reactor constant. This newly presented fluidic setup allows for the operation of several packed bed reactors combined with chip-based HPLC and mass spectrometric (MS) detection enabling the investigations of newly designed catalysts.