The two types of cannabinoid receptors named CB1 and CB2 are G protein coupled receptors. • Activation of the cannabinoid receptors causes inhibition of adenylate cyclase, and a subsequent decrease in the concentration of cyclic adenosine monophosphate in the cell, resulting in the inhibition of neurotransmission. • Δ9-Tetrahydrocannabinol (Δ9-THC), representing the psychoactive principle of Cannabis, was identified in 1964. • The CB1 receptor is expressed mainly in brain, lungs, liver, and kidneys; the CB2 receptor is expressed principally in the immune system. • Cannabinoid receptors are activated by phytocannabinoids (found in Cannabis), endocannabinoids (produced naturally in the body by humans and animals), and synthetic cannabinoids (produced chemically by humans).
Handbook of Cannabis and Related Pathologies
Mojgan Aghazadeh Tabrizi
Primo
2017
Abstract
The two types of cannabinoid receptors named CB1 and CB2 are G protein coupled receptors. • Activation of the cannabinoid receptors causes inhibition of adenylate cyclase, and a subsequent decrease in the concentration of cyclic adenosine monophosphate in the cell, resulting in the inhibition of neurotransmission. • Δ9-Tetrahydrocannabinol (Δ9-THC), representing the psychoactive principle of Cannabis, was identified in 1964. • The CB1 receptor is expressed mainly in brain, lungs, liver, and kidneys; the CB2 receptor is expressed principally in the immune system. • Cannabinoid receptors are activated by phytocannabinoids (found in Cannabis), endocannabinoids (produced naturally in the body by humans and animals), and synthetic cannabinoids (produced chemically by humans).I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
