Studies aiming at corroborating the regulation and function of the cortical cholinergic input system that postulates two separate modes of cholinergic neurotransmission. First a tonic component of cholinergic activity (changes on the scale of minutes) modulates the gain of thalamic input processing via stimulation of alfa4beta2 receptors expressed by thalamic afferents. Second , cue evoked glutamatergic release from thalamic afferents generates phasic or transient (scale of seconds) increases in acetylcholine release via stimulation of ionotropic glutamatergic receptors.
Regulation and function of the tonic component of cortical acetylcholine release.
PAOLONE, Giovanna;
2010
Abstract
Studies aiming at corroborating the regulation and function of the cortical cholinergic input system that postulates two separate modes of cholinergic neurotransmission. First a tonic component of cholinergic activity (changes on the scale of minutes) modulates the gain of thalamic input processing via stimulation of alfa4beta2 receptors expressed by thalamic afferents. Second , cue evoked glutamatergic release from thalamic afferents generates phasic or transient (scale of seconds) increases in acetylcholine release via stimulation of ionotropic glutamatergic receptors.File in questo prodotto:
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