In this project a colloidal preparation in the form of lecithin/chitosan nanoparticles is proposed to optimize TAM oral absorption, reducing the variability in bioavailability observed with tablets. The objectives were to study such nanoparticles loaded with tamoxifen (TAM-LCN) for their physico-chemical properties as well as for cytotoxicity and cell uptake in vitro on cell lines. Moreover, ex-vivo experiments with excised rat intestinal mucosa allowed investigating TAM permeation across the mucosa when formulated in nanoparticles. The contribution of mucoadhesion to drug permeation was assessed.
Autoassembled nanoparticles of lecithin/chitosan for oral delivery of the anticancer drug tamoxifen citrate
COLOMBO, Gaia;
2014
Abstract
In this project a colloidal preparation in the form of lecithin/chitosan nanoparticles is proposed to optimize TAM oral absorption, reducing the variability in bioavailability observed with tablets. The objectives were to study such nanoparticles loaded with tamoxifen (TAM-LCN) for their physico-chemical properties as well as for cytotoxicity and cell uptake in vitro on cell lines. Moreover, ex-vivo experiments with excised rat intestinal mucosa allowed investigating TAM permeation across the mucosa when formulated in nanoparticles. The contribution of mucoadhesion to drug permeation was assessed.File in questo prodotto:
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