The aim of this study was to investigate, using a Central Composite Design, the most influential process and formulation parameters on the construction of respirable amikacin spray-dried powders. The three factors, out of the previous five (drying temperature, feed rate and ethanol presence in the feed solution), were analyzed at three levels. The CCD let to identify the process factors combination to optimize the production of respirable amikacin spray dried powders for inhalation. Ethanol in the feed solution was found to promote significantly the amikacin spray dried powder respirability.
Construction of amikacin dry powders for inhalation by a Central Composite Design
COLOMBO, Gaia;
2015
Abstract
The aim of this study was to investigate, using a Central Composite Design, the most influential process and formulation parameters on the construction of respirable amikacin spray-dried powders. The three factors, out of the previous five (drying temperature, feed rate and ethanol presence in the feed solution), were analyzed at three levels. The CCD let to identify the process factors combination to optimize the production of respirable amikacin spray dried powders for inhalation. Ethanol in the feed solution was found to promote significantly the amikacin spray dried powder respirability.File in questo prodotto:
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