Objectives: Physical inactivity reduces quality of life and implies higher healthcare costs. Experimental bed-Rest (BR) model allows to analyze metabolic consequences of physical inactivity. The PANGeA group set 14-day horizontal BR to evaluate the effect of bed confinement on body composition, lipid and inflammatory profile. Methods: 23 healthy male subjects were enrolled, divided in 'YOUNG'(n=7;18-25 years) and 'Olders'(n=16;55-65 years). Body composition was assessed by BIA and blood samples were collected at baseline (BDC) and after 14-day BR (BR14). Among the 'OLD', 8 subjects underwent daily specific visual-spatial brain-training during BR (OLDBT). Results: At BDC body mass index was similar in the two groups while OLD showed higher levels of total- (204±39mg/dl vs. 151±15mg/dl;P: 0,002) and LDL-cholesterol (137±34mg/dl vs. 89±12mg/dl;P:0,002). At BR14, a significant decrease of body mass, free-fat Mass (FFM), total body water (TBW), body cell mass (BCM) and muscular mass (MM) was observed. Moreover, OLD showed a total- and LDL-cholesterol reduction (13% and 16%;P: 0,002) while the reduction in the YOUNG was not significant (4.3% and 4%). HDL-cholesterol was significantly reduced only in YOUNG (-17%; P=0,065). Both groups showed a significant increase in serum TNF-a. Althout not significant OLDBT showed an increase in HDL-c (+10%) opposite to the trend observed in OLD without brain traning (OLDNO-BT -10%). Similarly, Total-C/HDL-c ratio was 7% reduced in Old [OLDBT -18%; OLDNO-BT +2%] and 15% increased in YOUNG (P:0, 03). Conclusion: As expected BR was associated with a reduction in body mass, FFM, TBW, BCM and MM. This 'catabolic state' was associated with an increase inflammatory response and, in YOUNG, with a worsened lipid profile. Conversely, OLD showed an apparent lipid profile improvement which seems to be further modulated by brain-training. Further analysis are needed to investigate whether: 1) these changes are associated with decreased cardiovascular risk. 2) Brain-training might have a role in preventing BR associated modifications.
Effect of 14 days experimental horizontal bed rest on lipid and inflammatory profile.
MORIERI, Mario Luca;SOAVI, Cecilia;FRANCESCONI, Daniela;SANZ MOLINA, Juana Maria;DALLA NORA, Edoardo;ZULIANI, Giovanni;PASSARO, Angelina;
2014
Abstract
Objectives: Physical inactivity reduces quality of life and implies higher healthcare costs. Experimental bed-Rest (BR) model allows to analyze metabolic consequences of physical inactivity. The PANGeA group set 14-day horizontal BR to evaluate the effect of bed confinement on body composition, lipid and inflammatory profile. Methods: 23 healthy male subjects were enrolled, divided in 'YOUNG'(n=7;18-25 years) and 'Olders'(n=16;55-65 years). Body composition was assessed by BIA and blood samples were collected at baseline (BDC) and after 14-day BR (BR14). Among the 'OLD', 8 subjects underwent daily specific visual-spatial brain-training during BR (OLDBT). Results: At BDC body mass index was similar in the two groups while OLD showed higher levels of total- (204±39mg/dl vs. 151±15mg/dl;P: 0,002) and LDL-cholesterol (137±34mg/dl vs. 89±12mg/dl;P:0,002). At BR14, a significant decrease of body mass, free-fat Mass (FFM), total body water (TBW), body cell mass (BCM) and muscular mass (MM) was observed. Moreover, OLD showed a total- and LDL-cholesterol reduction (13% and 16%;P: 0,002) while the reduction in the YOUNG was not significant (4.3% and 4%). HDL-cholesterol was significantly reduced only in YOUNG (-17%; P=0,065). Both groups showed a significant increase in serum TNF-a. Althout not significant OLDBT showed an increase in HDL-c (+10%) opposite to the trend observed in OLD without brain traning (OLDNO-BT -10%). Similarly, Total-C/HDL-c ratio was 7% reduced in Old [OLDBT -18%; OLDNO-BT +2%] and 15% increased in YOUNG (P:0, 03). Conclusion: As expected BR was associated with a reduction in body mass, FFM, TBW, BCM and MM. This 'catabolic state' was associated with an increase inflammatory response and, in YOUNG, with a worsened lipid profile. Conversely, OLD showed an apparent lipid profile improvement which seems to be further modulated by brain-training. Further analysis are needed to investigate whether: 1) these changes are associated with decreased cardiovascular risk. 2) Brain-training might have a role in preventing BR associated modifications.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
