The aim of our project is to exploit miRNAs as drugs or targets in innovative therapeutic strategies for CLL and MM based on biological driven hypothesis, novel in vitro and in vivo preclinical models and delivery nanotechnologies. We propose an experimental platform which includes all steps from target identification (Task 1-2), bioreagent development (Task 3), in vivo preclinical validation (Task 4) and translation to clinical setting for assessment of the safety profile (Task 5) and final development as investigational new drug for FIRST in HUMAN studies (Task 6).
Associazione Italiana per la Ricerca sul Cancro AIRC 5xmille 2011: A research platform for miRNA-based treatment of multiple myeloma and chronic lymphocytic leukemia
NEGRINI, Massimo
2013
Abstract
The aim of our project is to exploit miRNAs as drugs or targets in innovative therapeutic strategies for CLL and MM based on biological driven hypothesis, novel in vitro and in vivo preclinical models and delivery nanotechnologies. We propose an experimental platform which includes all steps from target identification (Task 1-2), bioreagent development (Task 3), in vivo preclinical validation (Task 4) and translation to clinical setting for assessment of the safety profile (Task 5) and final development as investigational new drug for FIRST in HUMAN studies (Task 6).File in questo prodotto:
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