The heme endows human serum albumin (HSA) with reactivity and spectroscopic properties similar to those of hemoglobin and myoglobin. Here, warfarin and ibuprofen, the prototype ligands of Sudlow′s sites I and II, respectively, are reported to modulate allosterically peroxynitrite isomerization to nitrate by ferric heme-albumin (HSA-heme-Fe(III)).
Drug binding to human serum heme-albumin impairs allosterically peroxynitrite detoxification
COLOMBO, Gaia;MENEGATTI, Enea
2012
Abstract
The heme endows human serum albumin (HSA) with reactivity and spectroscopic properties similar to those of hemoglobin and myoglobin. Here, warfarin and ibuprofen, the prototype ligands of Sudlow′s sites I and II, respectively, are reported to modulate allosterically peroxynitrite isomerization to nitrate by ferric heme-albumin (HSA-heme-Fe(III)).File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
