In this work the influence of citric acid amount on the disintegration time of Dome Matrix® module in water was studied. Indeed, the amount of citric acid in the formulation influenced the tablet disintegration mechanism. In fact, tablets with large amount of citric acid (> 20% w/w) underwent erosion instead of disintegration. This was explained based on the high water solubility of citric acid.
Influence of citric acid amount on disintegration of Dome Matrix® modules
COLOMBO, Gaia
2012
Abstract
In this work the influence of citric acid amount on the disintegration time of Dome Matrix® module in water was studied. Indeed, the amount of citric acid in the formulation influenced the tablet disintegration mechanism. In fact, tablets with large amount of citric acid (> 20% w/w) underwent erosion instead of disintegration. This was explained based on the high water solubility of citric acid.File in questo prodotto:
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