Ribavirin (RBV) powder agglomerates were manufactured and characterized for nasal administration of the antiviral drug in animal viral encephalitis. In vitro and in vivo studies showed that the solid formulation was more effective than the solution with respect to RBV permeation and levels reached in CNS after nasal administration. The powder could be useful to treat viral brain infections in pets.
Enhancing ribavirin nose-to-brain delivery by powder formulation for veterinary CNS infections
COLOMBO, Gaia;MENEGATTI, Enea;
2011
Abstract
Ribavirin (RBV) powder agglomerates were manufactured and characterized for nasal administration of the antiviral drug in animal viral encephalitis. In vitro and in vivo studies showed that the solid formulation was more effective than the solution with respect to RBV permeation and levels reached in CNS after nasal administration. The powder could be useful to treat viral brain infections in pets.File in questo prodotto:
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