In vitro comparison of four anti-inflammatory topical medications

Measurement of in vitro release and diffusion across a barrier (artificial or biological) of the active ingredient sodium diclofenac from topical products (two originators and the corresponding generics) was carried out. Diclofenac release and availability appeared to be influenced by formulation characteristics, although the observed differences were reduced when skin was used instead of the artificial barrier. The information collected may be useful for the pharmacist when advising patients in the field of anti-inflammatory topical medications.